[Mixed Performance in the Three Major U.S. Stock Indexes] BlockBeats news, on August 28, according to BIT (bit.com) market data, U.S. stocks opened with mixed performance among the three major indexes: the Dow Jones rose 0.21%, the S&P 500 increased 0.05%, and the Nasdaq fell 0.09%. BioNTech (BNTX.O) dropped approximately 8.7%, announcing the termination of its Phase 2 clinical trial for colorectal cancer.