The next health revolution may come from individuals learning to control their own biology. In this conversation with a16z's Daisy Wolf, Andrew Huberman explores the remarkable ways emerging tools and cultural shifts are enabling people to optimize sleep, metabolism, focus, and performance. - How COVID accelerated a shift toward self-directed health and personal agency - Why resistance training, sunlight exposure, and sleep are the highest-leverage interventions for physical and cognitive performance - The transformative potential of GLP-1 drugs in treating obesity - Why peptides and emerging bio-optimization tools are gaining traction outside traditional medicine - The difference between reading biology (wearables, biomarkers) and writing to it ... and more. 0:00 Introduction 1:15 The health awakening, explained 7:02 MAHA's role in the health movement 13:05 GLP-1: Nearly one in seven Americans 18:37 The non-GLP peptide craze 25:16 Rogue experiments and low-dose GLP 31:40 Real-time cortisol sensing 44:39 The pet octopus and AI communication @hubermanlab @daisydwolf(a16z)