Mark Cuban scaled Cost Plus Drugs from about 100 generics to roughly 4,000 at a flat 15% markup, forcing incumbents to change prices in ways decades of policy never did. He thinks AI could transform healthcare, but it won't fix opaque prices and broken incentives on its own. Mark sits down with a16z's Julie Yoo and Erik Torenberg to discuss what he's learned building Cost Plus Drugs, why trust is its core product, and how greater transparency could put pressure on healthcare costs. They also explore why drugs designed for your DNA could cost close to nothing, the football field-sized drug plant his team shrank into tractor trailer-sized pods, his plan to make generics in Dallas for less than he pays manufacturers in India, and why every company will either be great at AI or go out of business. 0:50 Cost Plus beat decades of policy 3:15 111 generics to 4,000 drugs 5:00 A drug plant shrunk to 5K sq ft 5:55 $20M drug factories in a trailer 8:10 Hospital deals with zero denials 9:50 Why health plans are rigged 14:05 1,335 pages no human can check 18:35 "Where are they f**king me over?" 22:45 Making drugs cheaper than India 26:50 Why you still need entry-level hires 31:45 Nonprofit hospitals must offer aid 35:55 DNA-matched drugs for near $0 39:30 Why AI will mean more doctors 48:00 Mark's plan: "bye bye insurers" 52:25 Why AI labs' ads are useless 56:35 Get good at AI or go out of business YouTube: https://youtu.be/5UWDUD6qaM4 @mcuban @julesyoo @eriktorenberg