[U.S.-Iran Negotiations Shift Focus to Limiting Uranium Enrichment, Hormuz Strait Becomes Iran's 'Ultimate Weapon'] BlockBeats News, April 21: The U.S. and Iran may soon resume negotiations in Islamabad, and various signs suggest that Washington, in order to safeguard the global economic landscape, seems prepared to 'tacitly allow' Iran's control over the Hormuz Strait. Previously, a warning from former Russian President Dmitry Medvedev completely ignited concerns among Gulf nations: reopening the Hormuz Strait might already be the most significant outcome achievable in U.S.-Iran negotiations, but this falls far short of the broader de-escalation that Gulf countries value. Officials and analysts predict that the next round of negotiations, set to take place in Islamabad, will no longer focus on Iran's missile program or its regional proxies but will increasingly center on limiting uranium enrichment activities and addressing Iran's control over the Hormuz oil transportation corridor. This strategy of 'management' rather than 'dismantling' could allow Iran to further tighten its grip on Middle Eastern energy supplies. While this move prioritizes global economic stability, it excludes those nations most vulnerable to energy and security shocks from the formal decision-making process. Currently, the U.S. and Iran remain deadlocked on the issue of uranium enrichment, with Iran rejecting demands for 'zero enrichment.' Gulf nation sources have stated, 'Ultimately, the Hormuz Strait will become the final red line. Previously, this was never an issue, but now it is.' In this conflict, Iran's threat to Gulf shipping has shattered the long-standing taboo against controlling Hormuz, making the disruption of shipping a tangible bargaining chip on the negotiation table for the first time.