[The U.S.-Iran situation escalated dramatically overnight, evolving into large-scale military conflict, with four relatives of Khamenei killed] BlockBeats news, March 1: Yesterday, Trump announced that the United States and Israel jointly launched a 'major military operation' against Iran, targeting the destruction of Iran's nuclear facilities, missile capabilities, naval forces, and promoting regime change. Trump has repeatedly posted on Truth Social, claiming that Iran's Supreme Leader Khamenei was killed in the attack and calling it 'the best opportunity for the Iranian people to reclaim their country,' urging Iranians to rise up and overthrow the regime. He stated that the bombing would 'continue uninterrupted for a week or longer if necessary.' Israeli Prime Minister Netanyahu confirmed there are 'numerous indications' that Khamenei is 'no longer alive,' and said the operation targets Iran's leadership, missile systems, and air defense systems. Early this morning, the Israeli Defense Forces launched a new round of strikes on Iran's ballistic missile launchers and air defense systems. Iranian officials firmly denied Khamenei's death, stating he is 'safe and commanding on the battlefield,' accusing the U.S. and Israel of spreading 'psychological warfare.' Iranian state media reported that Khamenei is 'steadfastly commanding.' The attacks caused significant casualties in Iran: the Iranian Red Crescent reported at least 201 deaths and over 700 injuries; some reports mentioned a school being hit, resulting in dozens of student deaths, with total casualties nearing a thousand. The strikes affected 24 provinces in Iran, including areas near the Tehran presidential palace and Khamenei's residence. Sources close to the Iranian Supreme Leader's residence confirmed the deaths of Khamenei's daughter, son-in-law, and granddaughter. Additionally, it was revealed that one of Khamenei's daughters-in-law died in the morning attack on February 28. Iran quickly retaliated by launching hundreds of missiles and drones targeting Israeli territory and U.S. military bases in the Middle East (including locations in the UAE, Kuwait, Qatar, and Bahrain). The attacks resulted in at least one death in Abu Dhabi; Israel reported intercepting most missiles, though fragments caused casualties. The Iranian Revolutionary Guard announced 'unlimited, no red-line' retaliation and claimed to have closed the Strait of Hormuz (a critical oil passage), potentially further impacting the global energy market. The conflict is ongoing, with the U.S. and Israel stating they will continue their strikes, while Iran vows 'devastating retaliation.' The situation remains highly unstable, with risks of further escalation. As of the time of publication, Israeli emergency organizations reported that on the first day of the U.S.-Israel military operation against Iran, 121 Israelis were injured, and earlier reports indicated one death.